Research Papers

A Snake Toxin Derivative for Treatment of Hyponatremia and Polycystic Kidney Diseases.
Stanajic-Petrovic G, Keck M, Barbe P, Urman A, Correia E, Isnard P, Duong Van Huyen JP, Chmeis K, Diarra SS, Palea S, Theodoro F, Nguyen AL, Castelli F, Pruvost A, Zhao W, Mendre C, Mouillac B, Bienaimé F, Robin P, Kessler P, Llorens-Cortes C, Servent D, Nozach H, Maillère B, Guo D, Truillet C, Gilles N.
J Am Soc Nephrol. 2025 Feb 1;36(2):181-192. doi: 10.1681/ASN.0000000505.
Embracing the Versatility of Botulinum Neurotoxins in Conventional and New Therapeutic Applications.
Rasetti-Escargueil C, Palea S.
Toxins (Basel). 2024 Jun 4;16(6):261. doi: 10.3390/toxins16060261. PMID: 38922155 Free PMC article. Review.
Cell Plasticity in a Mouse Model of Benign Prostate Hyperplasia Drives Amplification of Androgen-Independent Epithelial Cell Populations Sensitive to Antioxidant Therapy.
Dos Santos L, Carbone F, Pacreau E, Diarra S, Luka M, Pigat N, Baures M, Navarro E, Anract J, Barry Delongchamps N, Cagnard N, Bost F, Nemazanyy I, Petitjean O, Hamaï A, Ménager M, Palea S, Guidotti JE, Goffin V.
Am J Pathol. 2024 Jan;194(1):30-51. doi: 10.1016/j.ajpath.2023.09.010.
A snake toxin as a theranostic agent for the type 2 vasopressin receptor.
Droctové L, Lancien M, Tran VL, Susset M, Jego B, Theodoro F, Kessler P, Mourier G, Robin P, Diarra SS, Palea S, Flahault A, Chorfa A, Corbani M, Llorens-Cortes C, Mouillac B, Mendre C, Pruvost A, Servent D, Truillet C, Gilles N.
Theranostics. 2020 Sep 18;10(25):11580-11594. doi: 10.7150/thno.47485. eCollection 2020. PMID: 33052234 Free PMC article.
Combined Sabal and Urtica Extracts (WS® 1541) Exert Anti-proliferative and Anti-inflammatory Effects in a Mouse Model of Benign Prostate Hyperplasia.
Pigat N, Reyes-Gomez E, Boutillon F, Palea S, Barry Delongchamps N, Koch E, Goffin V.
Front Pharmacol. 2019 Mar 29;10:311. doi: 10.3389/fphar.2019.00311.
Netupitant, a Potent and Highly Selective NK1 Receptor Antagonist, Alleviates Acetic Acid-Induced Bladder Overactivity in Anesthetized Guinea-Pigs.
Palea S, Guilloteau V, Rekik M, Lovati E, Guerard M, Guardia MA, Lluel P, Pietra C, Yoshiyama M.
Front Pharmacol. 2016 Aug 4;7:234. doi: 10.3389/fphar.2016.00234. eCollection 2016.
Erratum to: The characteristics of intrinsic complex micro-contractile activity in isolated strips of the rat bladder.
Gillespie JI, Rouget C, Palea S, Granato C, Birder L, Korstanje C.
Naunyn Schmiedebergs Arch Pharmacol. 2015 Sep;388(9):997. doi: 10.1007/s00210-015-1158-6. PMID: 26246052
Prostaglandin E2 excitatory effects on rat urinary bladder: a comparison between the β-adrenoceptor modulation of non-voiding activity in vivo and micro-contractile activity in vitro.
Granato C, Korstanje C, Guilloteau V, Rouget C, Palea S, Gillespie JI.
Naunyn Schmiedebergs Arch Pharmacol. 2015 Jul;388(7):727-35. doi: 10.1007/s00210-015-1139-9.
Beta adrenergic modulation of spontaneous microcontractions and electrical field-stimulated contractions in isolated strips of rat urinary bladder from normal animals and animals with partial bladder outflow obstruction.
Gillespie JI, Rouget C, Palea S, Granato C, Korstanje C.
Naunyn Schmiedebergs Arch Pharmacol. 2015 Jul;388(7):719-26. doi: 10.1007/s00210-015-1136-z
The characteristics of intrinsic complex micro-contractile activity in isolated strips of the rat bladder.
Gillespie JI, Rouget C, Palea S, Granato C, Birder L, Korstanje C.
Naunyn Schmiedebergs Arch Pharmacol. 2015 Jul;388(7):709-18. doi: 10.1007/s00210-015-1131-4.
The actions of prolonged exposure to cholinergic agonists on isolated bladder strips from the rat.
Gillespie JI, Rouget C, Palea S, Korstanje C.
Naunyn Schmiedebergs Arch Pharmacol. 2015 Jul;388(7):737-47. doi: 10.1007/s00210-015-1129-y.
Comparison of the effects of β3-adrenoceptor agonism on urinary bladder function in conscious, anesthetized, and spinal cord injured rats.
Beauval JB, Guilloteau V, Cappellini M, Westfall TD, Rischmann P, Palea S, Gamé X, Lluel P.
Neurourol Urodyn. 2015 Aug;34(6):578-85. doi: 10.1002/nau.22629.
The effect of 5-HT and electrical field stimulation on the contractility of the whole isolated urinary bladder of Suncus murinus.
Javid FA, Palea S.
Eur J Pharmacol. 2014 Jan 15;723:489-93. doi: 10.1016/j.ejphar.2013.10.024.
Modulation of nerve-evoked contractions by β3-adrenoceptor agonism in human and rat isolated urinary bladder.
Rouget C, Rekik M, Camparo P, Botto H, Rischmann P, Lluel P, Palea S, Westfall TD.
Pharmacol Res. 2014 Feb;80:14-20. doi: 10.1016/j.phrs.2013.12.006.
ADX71441, a novel, potent and selective positive allosteric modulator of the GABA(B) receptor, shows efficacy in rodent models of overactive bladder.
Kalinichev M, Palea S, Haddouk H, Royer-Urios I, Guilloteau V, Lluel P, Schneider M, Saporito M, Poli S.
Br J Pharmacol. 2014 Feb;171(4):995-1006. doi: 10.1111/bph.12517.
Relevance of the cyclophosphamide-induced cystitis model for pharmacological studies targeting inflammation and pain of the bladder.
Augé C, Chene G, Dubourdeau M, Desoubzdanne D, Corman B, Palea S, Lluel P, Vergnolle N, Coelho AM.
Eur J Pharmacol. 2013 May 5;707(1-3):32-40. doi: 10.1016/j.ejphar.2013.03.008.
Effects of ρ-Da1a a peptidic α(1)(A)-adrenoceptor antagonist in human isolated prostatic adenoma and anaesthetized rats.
Palea S, Maiga A, Guilloteau V, Rekik M, Guérard M, Rouget C, Rischmann P, Botto H, Camparo P, Lluel P, Gilles N.
Br J Pharmacol. 2013 Feb;168(3):618-31. doi: 10.1111/j.1476-5381.2012.02231.x.
Fenoterol functionally activates the β₃-adrenoceptor in human urinary bladder, comparison with rat and mouse: implications for drug discovery.
Palea S, Rekik M, Rouget C, Camparo P, Botto H, Rischmann P, Lluel P, Westfall TD.
Eur J Pharmacol. 2012 Sep 5;690(1-3):202-6. doi: 10.1016/j.ejphar.2012.06.036.
Modulation of non-voiding activity by the muscarinergic antagonist tolterodine and the β(3)-adrenoceptor agonist mirabegron in conscious rats with partial outflow obstruction.
Gillespie JI, Palea S, Guilloteau V, Guerard M, Lluel P, Korstanje C.
BJU Int. 2012 Jul;110(2 Pt 2):E132-42. doi: 10.1111/j.1464-410X.2012.11240.x. PMID: 22734512
G protein-coupled receptors, an unexploited animal toxin targets: Exploration of green mamba venom for novel drug candidates active against adrenoceptors.
Maïga A, Mourier G, Quinton L, Rouget C, Gales C, Denis C, Lluel P, Sénard JM, Palea S, Servent D, Gilles N.
Toxicon. 2012 Mar 15;59(4):487-96. doi: 10.1016/j.toxicon.2011.03.009.
Halothane-anesthetized rabbit: a new experimental model to test the effects of besipirdine and duloxetine on lower urinary tract function.
Pérez-Martínez FC, Vela-Navarrete R, Virseda J, Ocaña AV, Lluel P, Rekik M, Bienaymé H, Ferté J, Attali P, Palea S.
Urol Int. 2011;86(2):210-9. doi: 10.1159/000321226.
5-Hydroxytryptamine potentiates neurogenic contractions of rat isolated urinary bladder through both 5-HT(7) and 5-HT(2C) receptors.
Rekik M, Lluel P, Palea S.
Eur J Pharmacol. 2011 Jan 10;650(1):403-10. doi: 10.1016/j.ejphar.2010.10.027.
Isolation and pharmacological characterization of AdTx1, a natural peptide displaying specific insurmountable antagonism of the alpha1A-adrenoceptor.
Quinton L, Girard E, Maiga A, Rekik M, Lluel P, Masuyer G, Larregola M, Marquer C, Ciolek J, Magnin T, Wagner R, Molgó J, Thai R, Fruchart-Gaillard C, Mourier G, Chamot-Rooke J, Ménez A, Palea S, Servent D, Gilles N.
Br J Pharmacol. 2010 Jan 1;159(2):316-25. doi: 10.1111/j.1476-5381.2009.00532.x.
Involvement of beta(3)-adrenoceptors in mouse urinary bladder function: role in detrusor muscle relaxation and micturition reflex.
Deba A, Palea S, Rouget C, Westfall TD, Lluel P.
Eur J Pharmacol. 2009 Sep 15;618(1-3):76-83. doi: 10.1016/j.ejphar.2009.07.012.
Comparative effect of alfuzosin and tamsulosin on the contractile response of isolated rabbit prostatic and iris dilator smooth muscles: possible model for intraoperative floppy-iris syndrome.
Palea S, Chang DF, Rekik M, Regnier A, Lluel P.
J Cataract Refract Surg. 2008 Mar;34(3):489-96. doi: 10.1016/j.jcrs.2007.10.045. PMID: 18299077
Involvement of 5-hydroxytryptamine (HT)7 receptors in the 5-HT excitatory effects on the rat urinary bladder.
Palea S, Lluel P, Barras M, Duquenne C, Galzin AM, Arbilla S.
BJU Int. 2004 Nov;94(7):1125-31. doi: 10.1111/j.1464-410X.2004.05114.x. PMID: 15541139
Increased adrenergic contractility and decreased mRNA expression of NOS III in aging rat urinary bladders.
Lluel P, Palea S, Ribière P, Barras M, Teillet L, Corman B.
Fundam Clin Pharmacol. 2003 Oct;17(5):633-41. doi: 10.1046/j.1472-8206.2003.00187.x. PMID: 14703725
Comparison of the relaxant effects of alfuzosin, phentolamine and sildenafil on rabbit isolated corpus cavernosum.
Palea S, Barras M.
BJU Int. 2003 Jun;91(9):873-7. doi: 10.1046/j.1464-410x.2003.04229.x. PMID: 12780851
Age-related changes in urethrovesical coordination in male rats: relationship with bladder instability?
Lluel P, Deplanne V, Heudes D, Bruneval P, Palea S
Am J Physiol Regul Integr Comp Physiol. 2003 May;284(5):R1287-95. doi: 10.1152/ajpregu.00499.2001. Epub 2002 Dec 27. PMID: 12505867 Free article.
Cholinergic and purinergic contribution to the micturition reflex in conscious rats with long-term bladder outlet obstruction.
Lluel P, Barras M, Palea S.
Neurourol Urodyn. 2002;21(2):142-53. doi: 10.1002/nau.10007. PMID: 11857668
Functional and morphological modifications of the urinary bladder in aging female rats.
Lluel P, Palea S, Barras M, Grandadam F, Heudes D, Bruneval P, Corman B, Martin DJ
Am J Physiol Regul Integr Comp Physiol. 2000 Apr;278(4):R964-72. doi: 10.1152/ajpregu.2000.278.4.R964. PMID: 10749785 Free article.
Pharmacological and urodynamic changes in rat urinary bladder function after multiple pregnancies.
Grandadam F, Lluel P, Palea S, Martin DJ.
BJU Int. 1999 Nov;84(7):861-6. doi: 10.1046/j.1464-410x.1999.00282.x. PMID: 10532987
Involvement of spinal NK1 and opioids receptors in modulating the inhibitory effect of capsaicin on micturition reflex in the acute spinalized guinea pig.
Palea S, Pietra C.
J Urol. 1999 Mar;161(3):998-1005. PMID: 10022740
Pharmacological characterization of thromboxane and prostanoid receptors in human isolated urinary bladder.
Palea S, Toson G, Pietra C, Trist DG, Artibani W, Romano O, Corsi M.
Br J Pharmacol. 1998 Jul;124(5):865-72. doi: 10.1038/sj.bjp.0701903. PMID: 9692770 Free PMC article.
The adrenergic, cholinergic and NANC nerve-mediated contractions of the female rabbit bladder neck and proximal, medial and distal urethra.
Deplanne V, Palea S, Angel I.
Br J Pharmacol. 1998 Apr;123(8):1517-24. doi: 10.1038/sj.bjp.0701757. PMID: 9605556 Free PMC article.
The effect of ovariectomy on the contractile response of the rat isolated detrusor muscle and urethra.
Palea S, Angel I.
Life Sci. 1997;61(1):PL21-6. doi: 10.1016/s0024-3205(97)00363-9. PMID: 9200675
Pharmacological characterization of tachykinin NK2 receptors on isolated human urinary bladder, prostatic urethra and prostate.
Palea S, Corsi M, Artibani W, Ostardo E, Pietra C.
J Pharmacol Exp Ther. 1996 May;277(2):700-5. PMID: 8627548
Failure of the putative neuropeptide Y antagonists, benextramine and PYX-2, to inhibit Y2 receptors in rat isolated prostatic vas deferens.
Palea S, Corsi M, Rimland JM, Trist DG, Ratti E.
Br J Pharmacol. 1995 Nov;116(5):2401-6. doi: 10.1111/j.1476-5381.1995.tb15079.x.
Discrimination by benextramine between the NPY-Y1 receptor subtypes present in rabbit isolated vas deferens and saphenous vein.
Palea S, Corsi M, Rimland JM, Trist DG.
Br J Pharmacol. 1995 May;115(1):3-10. doi: 10.1111/j.1476-5381.1995.tb16317.x.
Evidence for the presence of both pre- and postjunctional P2-purinoceptor subtypes in human isolated urinary bladder.
Palea S, Pietra C, Trist DG, Artibani W, Calpista A, Corsi M.
Br J Pharmacol. 1995 Jan;114(1):35-40. doi: 10.1111/j.1476-5381.1995.tb16305.x.
A further analysis of the contraction induced by activation of cholecystokinin A receptors in guinea pig isolated ileum longitudinal muscle-myenteric plexus.
Corsi M, Palea S, Pietra C, Oliosi B, Gaviraghi G, Sugg E, Van Amsterdam FT, Trist DG.
J Pharmacol Exp Ther. 1994 Aug;270(2):734-40. PMID: 7520941
ADP beta S induces contraction of the human isolated urinary bladder through a purinoceptor subtype different from P2X and P2Y.
Palea S, Corsi M, Pietra C, Artibani W, Calpista A, Gaviraghi G, Trist DG.
J Pharmacol Exp Ther. 1994 Apr;269(1):193-7. PMID: 8169824
Evidence for purinergic neurotransmission in human urinary bladder affected by interstitial cystitis.
Palea S, Artibani W, Ostardo E, Trist DG, Pietra C.
J Urol. 1993 Dec;150(6):2007-12. doi: 10.1016/s0022-5347(17)35955-4. PMID: 8230554
Further studies on the effects of selective neurokinin agonists upon the activation of micturition reflex in rats. Evidence for a dual NK-1 receptor mediated excitatory and inhibitory activity.
Palea S, Dalforno G, Gaviraghi G, Hagan RM, Trist DG, Pietra C.
Neuropeptides. 1993 May;24(5):285-91. doi: 10.1016/0143-4179(93)90017-5. PMID: 7687043

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