Our Expertise Areas and Services for the Pre-Clinical R&D
Pharmacological and physiological studies on 3 key therapeutic areas:
Gastro-Intestinal
Pathologies:
IBD, IBS
Gastroparesis
Colon cancer
Tissues :
Stomach
Colon
Ileum
Liver
Uro-Genital
Pathologies:
BPH
Overactive Bladder
Interstitial cystisis
Prostate & Bladder cancers
Tissues :
Urinary bladder
Prostate
Urethra
Corpora cavernosa
Respiratory
Pathologies:
COPD
Asthma
IPF
Lung cancer
Tissues :
Nasal mucosa
Trachea
Lung
Bronchus
Translational Pharmacology
The challenge for Translational Pharmacology is to improve the predictive value of the tools that are used to qualify the efficacy of a drug candidate.
Our goal is to improve the predictivity of the pre-clinical studies by using:
– Human cells and fresh tissues isolated from the patients of interest
– In vivo models using transgenic mice mimicking the pathology of interest
Human Tissues Supply
– Consenting patient donor who did not receive any financial incentive
– Convention for the protection of human rights and dignity of human beings concerning applications of biology and medicine: “Convention on Human Rights and Biomedicine”
– Sources compliant with the highest international ethical guidelines
– French Ministry of Research authorizations for preparation, manipulation, import/export human tissues
Technological Platforms
A wide range of specialized technological platforms to perform proof-of-concept studies:
In vitro
– Cell cultures
– Histological studies
– Organ bath apparatus (myogenic and neurogenic contractility)
In vivo
– Ultra-performant metabolic cages for accurate separation of urine and feces
– In Vivo Imaging (RMI, SPECT, TEP, Ultra-High‐Frequency)
– Transgenesis (mice, zebrafish)
– Embryo cryo-preservation
Consultancy
Save both time and money: Our 30-years expertise available when you need it
– Identification of the best Experimental Models
– Study Plan optimization
– Evaluation of Therapeutic Switching opportunities
– Identification of potential Off-Targets by proprietary Bioinformatics tools
– Designing new drug formulations
