Our Expertise Areas and Services for the Pre-Clinical R&D

Pharmacological and physiological studies on 3 key therapeutic areas:


Gastro-Intestinal

Pathologies:

IBD, IBS
Gastroparesis
Colon cancer

Tissues :

Stomach
Colon
Ileum
Liver

Uro-Genital

Pathologies:

BPH
Overactive Bladder
Interstitial cystisis
Prostate & Bladder cancers

Tissues :

Urinary bladder
Prostate
Urethra
Corpora cavernosa

Respiratory

Pathologies:

COPD
Asthma
IPF
Lung cancer

Tissues :

Nasal mucosa
Trachea
Lung
Bronchus

Contact our scientific team for further information:

Translational Pharmacology

The challenge for Translational Pharmacology is to improve the predictive value of the tools that are used to qualify the efficacy of a drug candidate.

Our goal is to improve the predictivity of the pre-clinical studies by using:

– Human cells and fresh tissues isolated from the patients of interest

In vivo models using transgenic mice mimicking the pathology of interest

DNA molecules
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Human Tissues Supply

– Consenting patient donor who did not receive any financial incentive

– Convention for the protection of human rights and dignity of human beings concerning applications of biology and medicine: “Convention on Human Rights and Biomedicine”

– Sources compliant with the highest international ethical guidelines

– French Ministry of Research authorizations for preparation, manipulation, import/export human tissues

Technological Platforms

A wide range of specialized technological platforms to perform proof-of-concept studies:

In vitro

– Cell cultures
– Histological studies
– Organ bath apparatus (myogenic and neurogenic contractility)

In vivo

– Ultra-performant metabolic cages for accurate separation of urine and feces
In Vivo Imaging (RMI, SPECT, TEP, Ultra-High‐Frequency)
– Transgenesis (mice, zebrafish)
– Embryo cryo-preservation

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Male Patient Having Consultation With Doctor In Office

Consultancy

Save both time and money: Our 30-years expertise available when you need it

– Identification of the best Experimental Models

– Study Plan optimization

– Evaluation of Therapeutic Switching opportunities

– Identification of potential Off-Targets by proprietary Bioinformatics tools

– Designing new drug formulations